Tim Heidecker: I grew up in Allentown and we had Channel 69, no joke, which was just local car commercials, carpet stores. That and local news. Out in Philadelphia, there was this thing called Al Albert?s Showcase, which was this creepy old man in a tuxedo, who would have really little kids on doing songs and jokes. It was really low production value, creepy.
WASHINGTON (AP) ? Rules aimed at helping drivers avoid unintentionally backing over children, already overdue, are being delayed again following complaints from automakers that requiring rearview video cameras systems on new cars and trucks would be too expensive.
In a letter to lawmakers, Transportation Secretary Ray LaHood said his department needs more time for "research and data analysis" before it can issue regulations.
"I believe it is important to allot additional time to ensure that the final rule is appropriate and the underlying analysis is robust," LaHood wrote Tuesday. The letter didn't mention the auto industry's concerns.
More than a year ago, the National Highway Traffic Safety Administration proposed requiring improved driver rear visibility in new vehicles, a standard that in most cases would necessitate rear-mounted video cameras with in-vehicle display screens. The regulations were to be phased in, applying to all cars and light trucks by the 2014 model year.
The new rear visibility standard was required by a law that Congress passed in 2008 in response to dozens of accidents in which children were backed over. At issue in particular were blind zones in large sport utility vehicles and pickups.
Nearly 300 people are killed and 18,000 injured each year because of back-over accidents, according to NHTSA data. Many occur in driveways and parking lots. Nearly half the deaths involve children under age 5. The elderly also are frequent victims.
Lobbyists for the Alliance of Automobile Manufacturers met with White House officials in December about the proposed rules. Documents brought to the meeting by lobbyists, and posted online by the White House, urged the administration to permit manufacturers the option of meeting the proposed visibility standard through expanded mirrors on vehicles rather than cameras.
The documents pegged the cost to the industry of requiring cameras at $2.7 billion annually. But they said allowing automakers to meet the standard with mirrors instead would cost about $1 billion.
"We had urged the government to explore all the options, including mirrors with a wider field of vision," Gloria Bergquist, vice president of the alliance, said in an interview. "There are a variety of tools that could be used. Certainly the rearview cameras are available, and many people are buying them, so it would give consumers more options in how much extra they paid for these technologies."
Clarence Ditlow, executive director of the Center for Auto Safety, a consumer group, said providing that flexibility is a bad idea, especially since it is people outside the car who are being killed and injured, not the drivers.
"Safety should be for all, not some," he said. "Sure, a mirror is going to be cheaper, but will a mirror get the job done? The answer is no."
Mirrors only work if drivers remember to use them, Ditlow said. But video camera systems that include sensors usually beep or make other audible warnings that alert drivers to the presence of a person behind the vehicle, he said.
The government estimated the video systems would add $159 to $203 to the cost of each new vehicle. But if the vehicle already has a built-in GPS screen, the cost could be as low as $58, Bergquist said.
Automakers are also concerned that the cumulative effect of federal safety regulations is driving up the average price of a new car, which is now about $25,000, she said.
About 45 percent of 2012 model cars have rearview cameras as standard equipment, according to KidsAndCars.org, a safety group that championed the passage of the 2008 law. The cameras are an option on an additional 23 percent of models.
The 2008 law required the government to issue final rules to address back-over accidents by Feb. 28, 2011. LaHood extended that deadline twice previously.
In a majority of back-over accidents in which children were killed, the driver was a family member, according to KidsAndCars.
"The emotional tragedy is off the Richter scale," said Janette Fennell, president and founder of the group.
In a 2005 tragedy, Meredyth Bryant called to her 2-year-old daughter Annabelle to come out from behind a painting contractor's pickup truck in the driveway of the family's home near Richmond, Va., but it was too late. The contractor, who had no way to see the child, backed over Annabelle, killing her.
"These are very preventable accidents," Bryant said. "No one should have to die that way, especially an innocent child right in front of her mother."
___
Follow Joan Lowy at http://www.twitter.com/AP_Joan_Lowy
___
Online:
National Highway Traffic Safety Administration: http://www.nhtsa.gov
KidsAndCars.org: http://www.kidsandcars.org/
Alliance of Automobile Manufacturers: http://www.autoalliance.org/
In the not too distant future, you'll never be too far from home, as companies like AT&T rev up the ability to give consumers the means to control practically everything in the house through smartphones, tablets and anything else that's connected to the Internet.
At the Mobile World Congress in Barcelona, as part of the GSMA Connected House, AT&T unveiled?Digital Life,?a Web-based remote security and automation platform that will allow subscribers to open and close blinds, set thermostats and lighting timers, and lock doors and windows. If they're not at home, they can still do all these things from their devices, which will link to a cloud-based control panel. At home or away, they'll be able to see what's going on at a glance.
AT&T says Digital Life is?designed for self installation in the home or office. The carrier says consumers, small businesses and healthcare providers can benefit from the networking of devices such as motion detectors,?connected cameras, security keypads, window and door sensors, lighting and thermostat controls, smoke detectors and water sensors.
Here's a video about it:
The AT&T platform is expected to be available later this year.?
On Twitter, follow?Athima Chansanchai, who is also trying to keep her head above water in the?Google+?stream.
New Health And Fitness.Org - Health Information You Can Use
You walk out on the street and there is this bunch of spoilt teenagers who laugh at you?Or you attend these high class party and those arrogant ladies mock your beauty?Does that mole on you face embarrass you all the time?There is no need to get depressed or sad about it, because there is a solution to all the problems in the world.And this irritating skin problem has a natural solution too!
Skin tags or moles or warts, whatever you call it, is a very common skin problem that is encountered by many people.It is irritating and annoying and also contagious.If an appropriate treatment is not provided, it quickly spreads to the other parts of the skin.Hence, the elimination of these bothersome moles becomes inevitable.Even if there is no medical compulsion to get it removed, most of us want to look our best and these moles definitely are the enemies of beauty.
Many of you might have got the surgery done so many times and there might be regular visits to the dermatologists too.But that doesn?t have the effect anymore.One that it costs you a fortune, and even if you are rich enough, you don?t want that pain each time a mole or a wart resurfaces.The pain, the cost and more than anything the scars are all the factors that are needed to take you away from the surgical remedy.
Nowadays, many methods like laser treatment, ointments and medicines have been out to treat the skin tags.Many of them work while some don?t and some only work on temporary basis.Pharmaceutical companies are in a race to produce some natural mole removal medicines or ointments.Such very reputed company has given dermatend.It is easy to use and highly efficient.Dermatend ultra is even a better version of the medicine which yields result in almost 24 hours.Believe me, it really works!You can be stress free as this ointment is naturally based and does not have any side effects.
The mole and the warts have to be first scrapped out from the skin to apply the ointment.Then apply the cream and the effect will be apparent.One point to keep in mind to get the best results is that the directions should be followed precisely or the medicine would not be effective.
Getting thumbs up from many users, dermatend ultra is a very effective natural mole removal medicine.It can be a good replacement for the pain giving surgeries and will produce a long lasting effect.
Need more information on natural mole removal? Visit http://www.skin-tag-removal.org/
Note: That is section of a 4 component set to slice your personal developments understanding contour. The remainder is found in the Town Monk website.
Step Three: Make a decision what for you to do and in which you wish to go.
Now that youve cleansed the are like a magnet from the gem that is definitely you, its the perfect time to get started shaping and sprucing up it.
- Record out anything you want. Tell the truth. Injure yourself. Make-believe there are no limitations that you have on a regular basis and cash you?ll need. Make-believe no-you are going to disapprove of yourself anything you do will probably be celebrated on your parents, spouse, and buddies.
Dont pinpoint the terrible. For example, in case you have an unsatisfactory relationship, dont point out I emule dont require a terrible relationship. What you eagerly want is a caring partner. The positioning should go more into this, for now, be aware that if you concentrate on the bad, thats what you would get.
- Next, for each purpose you wish to reach, number out all the things you can do to accomplish what you long for. Brainstorm a few and number them for each purpose you wish to reach.
- Also, next to each and every purpose, jot down anything that you suspect are stopping you from accomplishing these ambitions. How might you overcome these limitations? For example, if your purpose is to find a boyfriend, therefore you believe that that you?re fat and unfashionable venture out shopping opera using a stylish close friend and enroll in a health and fitness center. Its that straightforward.
- While you?re in internet, number out all the jobs you wish about you. Adding everything you are offering your favorite man or woman inside your life. Then what you can offer you in the job, and finally everything you can provide the community!
Keep these directories a place you love in the bedroom and make reference to issues. Enhance it about you can. Produce your lifetime to help you to consistently add to these directories. This is simply a tiny exercise to build up on your own-self-esteem and make you pinpoint the good in you and your living instead of the terrible.
- Consider online games a list of what you?re really pleased for? Enhance it regular, consistently. Whatever you are pleased for, you?ll receive the rest of. And will also also train your mind to pay attention to the nice instead of the terrible.
By determining what you long for, and being aware of you can do it, you have begun to take responsibility for your living. Therefore, right away on your own-self-esteem and self-confidence will expand. Look around the remainder of this website for support on accomplishing your ambitions, I attempt to get this to web site rather extensive and there has to be anything in the following to help you in a purpose you?ve got. In case there isnt, there isn?t a lack of knowledge in a different place.
Bookmark the Town Monk web site and come back to it time and again. Improved property value . a change inside your life and joy.
ScienceDaily (Feb. 28, 2012) ? Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma.
Vemurafenib resistance is characterized by a diminished apoptosis (programmed cancer cell death) response. According to the researchers, the balance between apoptosis and cell survival is regulated by a family of proteins. The survival of melanoma cells is controlled, in part, by an anti-apoptotic protein (Mcl-1) that is regulated by a particular kind of inhibitor.
Their current findings, tested in six different models of vemurafenib resistance and in both test tube studies and in melanoma patients, demonstrated an induced apoptosis response and tumor regression when the XL888 inhibitor restored the effectiveness of vemurafenib.
The study appeared in a recent issue of Clinical Cancer Research, a publication of the American Association for Cancer Research.
"The impressive clinical response of melanoma patients to vemurafenib has been limited by drug resistance, a considerable challenge for which no management strategies previously existed," said study co-author Keiran S. M. Smalley, Ph.D., of Moffitt's departments of Molecular Oncology and Cutaneous Oncology. "However, we have demonstrated for the first time that the heat shock protein-90 (HSP90) inhibitor XL888 overcomes resistance through a number of mechanisms."
The diversity of resistance mechanism has been expected to complicate the design of future clinical trials to prevent or treat resistance to inhibitors such as vemurafenib.
"That expectation led us to hypothesize that inhibitor resistance might best be managed through broadly targeted strategies that inhibit multiple pathways simultaneously," explained Smalley.
The HSP90 family was known to maintain cancer cells by regulating cancer cells, making it a good target for treatment. According to the authors, the combination of vemurafenib and XL888 overcame vemurafenib resistance by targeting HSP90 through multiple signaling pathways.
There was already evidence that HSP90 inhibitors could overcome multiple drug chemotherapy resistance mechanisms in a number of cancers, including non-small lung cancer and breast cancer. Because XL888 is a novel, orally available inhibitor of HSP90, the researchers hoped that it would arrest the cancer cell cycle in melanoma cell lines.
In their study, the inhibition of HSP90 led to the degradation of the anti-apoptopiuc Mcl-1 protein. The responses to XL888 were characterized as "highly durable with no resistant colonies emerging following four weeks of continuous drug treatment." In other studies not using XL888, resistant colonies "emerged in every case," they reported.
"We have shown for the first time that all of the signaling proteins implicated in vemurafenib resistance are 'clients' of HSP90 and that inhibition of HSP90 can restore sensitivity to vemurafenib," concluded Smalley and his colleagues. "Our study provides the rationale for the dual targeting of HSP90 with XL888 and vemurafenib in treating melanoma patients in order to limit or prevent chemotherapy resistance."
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The above story is reprinted from materials provided by Moffitt Cancer Center, via Newswise.
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Journal Reference:
K. H. T. Paraiso, E. Haarberg, E. Wood, V. W. Rebecca, Y. A. Chen, Y. Xiang, A. Ribas, R. S. Lo, J. S. Weber, V. K. Sondak, J. John, A. A. Sarnaik, J. Koomen, K. S. M. Smalley. The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms. Clinical Cancer Research, 2012; DOI: 10.1158/1078-0432.CCR-11-2612
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Running any business is not an easy task! Lot of finance is required in continuing operations, expanding, and exploring new opportunities. Business loans are mainly designed to help an individual in running business, by providing sufficient assistance, when required! Whether you are owner of a small, medium-sized, or a big company, you are free to apply.
For getting assistance through business loans, you should be having few relevant documents ready with you! These may include your business profile, future plans, income proof, gross profit, bank statements from operating account, proof of continuity of current business, and so on. However, documents may vary from lender to lender!
Business loans are available in secured and unsecured forms! To have funds through secured loans, you need to put some security. You may put residential and commercial property, working capital, etc. as collateral! On the other hand, unsecured loans are collateral free. But, interest rates may be marginally higher.
With the help of amount obtained through business loans, you may purchase space for opening new office, purchase machineries, reconstruct existing office, settle down debts, finance research and development work, and so on.
In business loans, exact amount that you may obtain is based on several factors! These may include requirements, value of collateral (if any), current circumstances, repayment ability, lender?s policy, and profit in business. Repayment term is very flexible and is decided based on approved amount!
Business loans are available for all sorts of credit holders! Issues like defaults, arrears, bankruptcy, insolvency, County Court Judgments, skipped payments, or due payments, are also acceptable. But, poor credit may require you to pay comparatively higher interest rates!
For Business start up loans, round the clock, application form remains available online! At per your convenience, you may do some research, go through different deals offered by different lenders, compare different rate quotes, and apply for the best deal for your requirement. You just need to fill few details in the short and simple application form. All the information provided by you is kept confidential! Your application process will get completed in just few minutes. So, online process helps in saving lot of valuable time!
Chaste Rama has no formal degree in finance, but year of work that he has put in the finance industry make him expert in financial matter. To find unsecured business loan, bad debt business loans uk, unsecured business loan UK, unsecured small business loan, cheap unsecured business loan visit http://www.unsecuredbusinessloans.org.uk
Home improvement projects can seem like a great time to pull out the how to handbook or to search the internet for Home Improvements 101. There are a great many ways that you can save money by doing home improvements. You may be able to patch holes, replace flooring,Coach handbags outlet store, hang wallpaper, paint,Louis Vuitton Handbags Outlet, and replace the cabinets and many other projects that will save mega money. One area that you should avoid trying to save money is by doing your own electrical work.
The weight of having to tear out the work done and the expense of the fine are done as a means to hinder people from doing their own home improvement electrical work. Electrical work must be done correctly. Faulty wiring can result in smoking wires and short outs in appliances or light fixtures. The worse thing that can happen with incorrect wiring is a fire. Fires that are caused by incorrect wiring are labeled as such by the fire department and are then investigated by the township.
Electrical contractors are licensed through the state which they live in. NJ Electrician must complete the following criteria. They must be 21 years of age. They must have completed high school or have their GED. They must also have one of the following criteria met: They must have five years of experience in electrical wiring or heat or power installation. They must completed a four year apprenticeship approved through the Board and one year experience approved by the Board. They must have completed 8,Gucci handbags Outlet,000 hours of electrical hands on work and 576 hours of study completed in the classroom. Or,Louis Vuitton Handbags Cheap, lastly, they must have received their Electrical Engineering bachelor's degree and two years of work approved by the Board. As you can see the training that is required by NJ is intense. Electrical work must be done correctly to ensure safety.
December trading was notably stronger with growth in Group like-for-like sales for the five weeks to 31 December of 6.5% including VAT,? company said in a statement released on Tuesday.
In New Jersey the owner or lease holder of the building or home is required by law to secure permits and to hire a licensed New Jersey electrician to do all electrical work. The hired electrical contractor usually will apply for these permits for you. The township or county will then come and check the work being done. The NJ electrician will work with the township to ensure that all codes are adhered to. Upon completion the work will receive approval from the township. If you are caught doing work without a permit a fine will be issued. The work will often be required to be removed and redone by a professional licensed NJ electrician.
But part of this increase is also explained by the Debenhams? slashed prices by up to 40 per cent in a week-long promotion in November and was considered by analysts to be one of the most aggressive discounters in the seasonal period.
Debenhams recognised that sales at stores open over a year, excluding VAT sales tax, were flat in the 18 weeks to January 7. This compared with analysts? forecasts of sales down 0.9% from a range of flat to down 3.2 per cent,Burberry handbags online, according to a Reuters poll of nine.
Shoud investors follow billionaire Warren Buffett and buy shares of JPM? Paul Miller, FBR Capital Markets, and Carter Worth, Oppenheimer Asset Management , weigh in.
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Business & financial news headlines from msnbc.com
Mass. General researchers isolate egg-producing stem cells from adult human ovariesPublic release date: 26-Feb-2012 [ | E-mail | Share ]
Contact: Sue McGreevey smcgreevey@partners.org 617-724-2764 Massachusetts General Hospital
Findings support continued egg-cell production throughout reproductive life
For the first time, Massachusetts General Hospital (MGH) researchers have isolated egg-producing stem cells from the ovaries of reproductive age women and shown these cells can produce what appear to be normal egg cells or oocytes. In the March issue of Nature Medicine, the team from the Vincent Center for Reproductive Biology at MGH reports the latest follow-up study to their now-landmark 2004 Nature paper that first suggested female mammals continue producing egg cells into adulthood.
"The primary objective of the current study was to prove that oocyte-producing stem cells do in fact exist in the ovaries of women during reproductive life, which we feel this study demonstrates very clearly," says Jonathan Tilly, PhD, director of the Vincent Center for Reproductive Biology in the MGH Vincent Department of Obstetrics and Gynecology, who led the study. "The discovery of oocyte precursor cells in adult human ovaries, coupled with the fact that these cells share the same characteristic features of their mouse counterparts that produce fully functional eggs, opens the door for development of unprecedented technologies to overcome infertility in women and perhaps even delay the timing of ovarian failure."
The 2004 report from Tilly's team challenged the fundamental belief, held since the 1950s, that female mammals are born with a finite supply of eggs that is depleted throughout life and exhausted at menopause. That paper and a 2005 follow-up published in Cell showing that bone marrow or blood cell transplants could restore oocyte production in adult female mice after fertility-destroying chemotherapy were controversial; but in the intervening years, several studies from the MGH-Vincent group and other researchers around the world have supported Tilly's work and conclusions.
These supporting studies include a 2007 Journal of Clinical Oncology report from the MGH-Vincent team that showed female mice receiving bone marrow transplants after oocyte-destroying chemotherapy were able to have successful pregnancies, delivering pups that were their genetic offspring and not of the marrow donors. A 2009 study from a team at Shanghai Jiao Tong University in China, published in Nature Cell Biology, not only isolated and cultured oocyte-producing stem cells (OSCs) from adult mice but also showed that those OSCs, after transplantation into the ovaries of chemotherapy-treated female mice, gave rise to mature oocytes that were ovulated, fertilized and developed into healthy offspring.
"That study singlehandedly deflated many of the arguments from critics of our earlier Nature paper by showing that oocyte-producing stem cells exist in mice and could develop into fully functional eggs," says Tilly. Another paper from a west-coast biotechnology company, published in Differentiation in 2010, provided further independent confirmation of Tilly's earlier conclusions regarding the presence of oocyte-producing stem cells in ovaries of adult mice.
Tilly is quick to point out, however, "These follow-up studies, while providing definitive evidence that oocyte-producing stem cells exist in ovaries of adult female mammals, were not without their limitations, leaving the question open in some scientific circles of whether the adult oocyte pool can be renewed. For example, the protocol used to isolate OSCs in the 2009 Nature Cell Biology study is a relatively crude approach that often results in the contamination of desired cells by other cell types." To address this, the MGH-Vincent team developed and validated a much more precise cell-sorting technique to isolate OSCs without contamination from other cells.
The 2009 study from China also had isolated OSCs based on cell-surface expression of a marker protein called Ddx4 or Mvh, which previously had been found only in the cytoplasm of oocytes. This apparent contradiction with earlier studies raised concerns over the validity of the protocol. Using their state-of-the-art fluorescence-activated cell sorting techniques, the MGH-Vincent team verified that, while the marker protein Ddx4 was indeed located inside oocytes, it was expressed on the surface of a rare and distinct population of ovarian cells identified by numerous genetic markers and functional tests as OSCs.
To examine the functional capabilities of the cells isolated with their new protocol, the investigators injected green fluorescent protein (GFP)-labeled mouse OSCs into the ovaries of normal adult mice. Several months later, examination of the recipient mouse ovaries revealed follicles containing oocytes with and without the marker protein. GFP-labeled and unlabeled oocytes also were found in cell clusters flushed from the animals' oviducts after induced ovulation. The GFP-labeled mouse eggs retrieved from the oviducts were successfully fertilized in vitro and produced embryos that progressed to the hatching blastocyst stage, a sign of normal developmental potential. Additionally, although the Chinese team had transplanted OSCs into ovaries of mice previously treated with chemotherapy, the MGH-Vincent team showed that it was not necessary to damage the recipient mouse ovaries with toxic drugs before introducing OSCs.
In their last two experiments, which Tilly considers to be the most groundbreaking, the MGH-Vincent team used their new cell-sorting techniques to isolate potential OSCs from adult human ovaries. The cells obtained shared all of the genetic and growth properties of the equivalent cells isolated from adult mouse ovaries, and like mouse OSCs, were able to spontaneously form cells with characteristic features of oocytes. Not only did these oocytes formed in culture dishes have the physical appearance and gene expression patterns of oocytes seen in human ovaries as was the case in parallel mouse experiments but some of these in-vitro-formed cells had only half of the genetic material normally found in all other cells of the body. That observation indicates that these oocytes had progressed through meiosis, a cell-division process unique to the formation of mature eggs and sperm.
The researchers next injected GFP-labeled human OSCs into biopsied human ovarian tissue that was then grafted beneath the skin of immune-system-deficient mice. Examination of the human tissue grafts 7 to 14 days later revealed immature human follicles with GFP-negative oocytes, probably present in the human tissue before OSC injection and grafting, as well as numerous immature human follicles with GFP-positive oocytes that would have originated from the injected human OSCs.
"These experiments provide pivotal proof-of-concept that human OSCs reintroduced into adult human ovarian tissue performed their expected function of generating new oocytes that become enclosed by host cells to form new follicles," says Tilly, a professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School and chief of Research at the MGH Vincent Department of Obstetrics and Gynecology. "These outcomes are exactly what we see if we perform the same experiments using GFP-expressing mouse OSCs, and GFP-expressing mouse oocytes formed that way go on to develop into fully functional eggs.
"In this paper we provide the three key pieces of evidence requested by those who have been skeptical of our previous work," he adds. "We developed and extensively validated a cell-sorting protocol to reliably purify OSCs from adult mammalian ovaries, proving once again that these very special cells exist. We tested the function of mouse oocytes produced by these OSCs and showed that they can be fertilized to produce healthy embryos. And we identified and characterized an equivalent population of oocyte-producing stem cells isolated from adult human ovaries."
Among the many potential clinical applications for these findings that Tilly's team is currently exploring are the establishment of human OSC banks since these cells, unlike human oocytes, can be frozen and thawed without damage the identification of hormones and factors that accelerate the formation of oocytes from human OSCs, the development of mature human oocytes from OSCs for in vitro fertilization, and other approaches to improve the outcomes of IVF and other infertility treatments.
###
Tilly notes that an essential part of his group's accomplishment was collaboration with study co-author Yasushi Takai, MD, PhD, a former MGH research fellow on Tilly's team and now a faculty member at Saitama Medical University in Japan. Working with his clinical colleagues at Saitama, Takai was able to provide healthy ovarian tissue from consenting patients undergoing sex reassignment surgery, many in their 20s and early 30s. Co-lead authors of the Nature Medicine report are Yvonne White, PhD, and Dori Woods, PhD, of the Vincent Center for Reproductive Biology at MGH. Additional co-authors are Osamu Ishihara, MD, PhD, and Hiroyuki Seki, MD, PhD, of Saitama Medical University.
The study was supported by a 10-year MERIT Award to Tilly from the National Institute on Aging, a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health, the Henry and Vivian Rosenberg Philanthropic Fund, the Sea Breeze Foundation, and Vincent Memorial Hospital Research Funds. Tilly is a co-founder of OvaScience, Inc. (www.ovascience.com), which has licensed the commercial potential of these and other patent-protected findings of the MGH-Vincent team for development of new fertility-enhancing procedures.
Massachusetts General Hospital (www.massgeneral.org), founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
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Mass. General researchers isolate egg-producing stem cells from adult human ovariesPublic release date: 26-Feb-2012 [ | E-mail | Share ]
Contact: Sue McGreevey smcgreevey@partners.org 617-724-2764 Massachusetts General Hospital
Findings support continued egg-cell production throughout reproductive life
For the first time, Massachusetts General Hospital (MGH) researchers have isolated egg-producing stem cells from the ovaries of reproductive age women and shown these cells can produce what appear to be normal egg cells or oocytes. In the March issue of Nature Medicine, the team from the Vincent Center for Reproductive Biology at MGH reports the latest follow-up study to their now-landmark 2004 Nature paper that first suggested female mammals continue producing egg cells into adulthood.
"The primary objective of the current study was to prove that oocyte-producing stem cells do in fact exist in the ovaries of women during reproductive life, which we feel this study demonstrates very clearly," says Jonathan Tilly, PhD, director of the Vincent Center for Reproductive Biology in the MGH Vincent Department of Obstetrics and Gynecology, who led the study. "The discovery of oocyte precursor cells in adult human ovaries, coupled with the fact that these cells share the same characteristic features of their mouse counterparts that produce fully functional eggs, opens the door for development of unprecedented technologies to overcome infertility in women and perhaps even delay the timing of ovarian failure."
The 2004 report from Tilly's team challenged the fundamental belief, held since the 1950s, that female mammals are born with a finite supply of eggs that is depleted throughout life and exhausted at menopause. That paper and a 2005 follow-up published in Cell showing that bone marrow or blood cell transplants could restore oocyte production in adult female mice after fertility-destroying chemotherapy were controversial; but in the intervening years, several studies from the MGH-Vincent group and other researchers around the world have supported Tilly's work and conclusions.
These supporting studies include a 2007 Journal of Clinical Oncology report from the MGH-Vincent team that showed female mice receiving bone marrow transplants after oocyte-destroying chemotherapy were able to have successful pregnancies, delivering pups that were their genetic offspring and not of the marrow donors. A 2009 study from a team at Shanghai Jiao Tong University in China, published in Nature Cell Biology, not only isolated and cultured oocyte-producing stem cells (OSCs) from adult mice but also showed that those OSCs, after transplantation into the ovaries of chemotherapy-treated female mice, gave rise to mature oocytes that were ovulated, fertilized and developed into healthy offspring.
"That study singlehandedly deflated many of the arguments from critics of our earlier Nature paper by showing that oocyte-producing stem cells exist in mice and could develop into fully functional eggs," says Tilly. Another paper from a west-coast biotechnology company, published in Differentiation in 2010, provided further independent confirmation of Tilly's earlier conclusions regarding the presence of oocyte-producing stem cells in ovaries of adult mice.
Tilly is quick to point out, however, "These follow-up studies, while providing definitive evidence that oocyte-producing stem cells exist in ovaries of adult female mammals, were not without their limitations, leaving the question open in some scientific circles of whether the adult oocyte pool can be renewed. For example, the protocol used to isolate OSCs in the 2009 Nature Cell Biology study is a relatively crude approach that often results in the contamination of desired cells by other cell types." To address this, the MGH-Vincent team developed and validated a much more precise cell-sorting technique to isolate OSCs without contamination from other cells.
The 2009 study from China also had isolated OSCs based on cell-surface expression of a marker protein called Ddx4 or Mvh, which previously had been found only in the cytoplasm of oocytes. This apparent contradiction with earlier studies raised concerns over the validity of the protocol. Using their state-of-the-art fluorescence-activated cell sorting techniques, the MGH-Vincent team verified that, while the marker protein Ddx4 was indeed located inside oocytes, it was expressed on the surface of a rare and distinct population of ovarian cells identified by numerous genetic markers and functional tests as OSCs.
To examine the functional capabilities of the cells isolated with their new protocol, the investigators injected green fluorescent protein (GFP)-labeled mouse OSCs into the ovaries of normal adult mice. Several months later, examination of the recipient mouse ovaries revealed follicles containing oocytes with and without the marker protein. GFP-labeled and unlabeled oocytes also were found in cell clusters flushed from the animals' oviducts after induced ovulation. The GFP-labeled mouse eggs retrieved from the oviducts were successfully fertilized in vitro and produced embryos that progressed to the hatching blastocyst stage, a sign of normal developmental potential. Additionally, although the Chinese team had transplanted OSCs into ovaries of mice previously treated with chemotherapy, the MGH-Vincent team showed that it was not necessary to damage the recipient mouse ovaries with toxic drugs before introducing OSCs.
In their last two experiments, which Tilly considers to be the most groundbreaking, the MGH-Vincent team used their new cell-sorting techniques to isolate potential OSCs from adult human ovaries. The cells obtained shared all of the genetic and growth properties of the equivalent cells isolated from adult mouse ovaries, and like mouse OSCs, were able to spontaneously form cells with characteristic features of oocytes. Not only did these oocytes formed in culture dishes have the physical appearance and gene expression patterns of oocytes seen in human ovaries as was the case in parallel mouse experiments but some of these in-vitro-formed cells had only half of the genetic material normally found in all other cells of the body. That observation indicates that these oocytes had progressed through meiosis, a cell-division process unique to the formation of mature eggs and sperm.
The researchers next injected GFP-labeled human OSCs into biopsied human ovarian tissue that was then grafted beneath the skin of immune-system-deficient mice. Examination of the human tissue grafts 7 to 14 days later revealed immature human follicles with GFP-negative oocytes, probably present in the human tissue before OSC injection and grafting, as well as numerous immature human follicles with GFP-positive oocytes that would have originated from the injected human OSCs.
"These experiments provide pivotal proof-of-concept that human OSCs reintroduced into adult human ovarian tissue performed their expected function of generating new oocytes that become enclosed by host cells to form new follicles," says Tilly, a professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School and chief of Research at the MGH Vincent Department of Obstetrics and Gynecology. "These outcomes are exactly what we see if we perform the same experiments using GFP-expressing mouse OSCs, and GFP-expressing mouse oocytes formed that way go on to develop into fully functional eggs.
"In this paper we provide the three key pieces of evidence requested by those who have been skeptical of our previous work," he adds. "We developed and extensively validated a cell-sorting protocol to reliably purify OSCs from adult mammalian ovaries, proving once again that these very special cells exist. We tested the function of mouse oocytes produced by these OSCs and showed that they can be fertilized to produce healthy embryos. And we identified and characterized an equivalent population of oocyte-producing stem cells isolated from adult human ovaries."
Among the many potential clinical applications for these findings that Tilly's team is currently exploring are the establishment of human OSC banks since these cells, unlike human oocytes, can be frozen and thawed without damage the identification of hormones and factors that accelerate the formation of oocytes from human OSCs, the development of mature human oocytes from OSCs for in vitro fertilization, and other approaches to improve the outcomes of IVF and other infertility treatments.
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Tilly notes that an essential part of his group's accomplishment was collaboration with study co-author Yasushi Takai, MD, PhD, a former MGH research fellow on Tilly's team and now a faculty member at Saitama Medical University in Japan. Working with his clinical colleagues at Saitama, Takai was able to provide healthy ovarian tissue from consenting patients undergoing sex reassignment surgery, many in their 20s and early 30s. Co-lead authors of the Nature Medicine report are Yvonne White, PhD, and Dori Woods, PhD, of the Vincent Center for Reproductive Biology at MGH. Additional co-authors are Osamu Ishihara, MD, PhD, and Hiroyuki Seki, MD, PhD, of Saitama Medical University.
The study was supported by a 10-year MERIT Award to Tilly from the National Institute on Aging, a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health, the Henry and Vivian Rosenberg Philanthropic Fund, the Sea Breeze Foundation, and Vincent Memorial Hospital Research Funds. Tilly is a co-founder of OvaScience, Inc. (www.ovascience.com), which has licensed the commercial potential of these and other patent-protected findings of the MGH-Vincent team for development of new fertility-enhancing procedures.
Massachusetts General Hospital (www.massgeneral.org), founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
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New Health And Fitness.Org - Health Information You Can Use
The health of your children is directly related to the state of their teeth and how healthy they actually are. Your children?s teeth should be important to you and them, which is why you need to monitor what the everyday. You may have to be persistent in impressing upon them how important their teeth are. If you are a parent, you will enjoy this article which will show you how to get your kids to take care of their teeth every single day.
Whether you are an adult, or a child, it is important that you visit the dentist on a regular basis. Even if your kids do not have dental problems, you should visit the dentist with them twice a year. This way, if you have any problems, they can be addressed immediately. During her checkup, you should have your teeth cleaned to make sure everything is okay. Do you have young children? If you do, a pediatric dentist is probably your best solution. While your own dentist may be good with kids, a pediatric dentist is often the best choice. Pediatric dentists will be able to spot problems much more quickly because they are trained to work with small children.
Just because your children have baby teeth which will eventually fall out, this does not mean you should ignore them. Baby teeth are notorious for rotting and causing infections within the mouth which can spread to nerves and cause considerable damage. As you probably guessed, toothaches will manifest. Early loss of baby teeth can actually cause permanent teeth to grow in at strange angles. A child?s mental health is sometimes correlated with ?milk teeth? or baby teeth. Learning how to speak, and also chewing food, is part of this topic. Never neglect your child?s baby teeth for these reasons.
Tests prove that children currently are at higher risk of being over a healthy weight than ever. Some of these studies also show that overweight children are also inclined to have more trouble with tooth decay. When you consider that overweight kids are overeaters; you can just about figure that harm will ultimately come to their teeth as a result. Being a parent makes this something you need to look out for. If your child has an unusually high number of cavities; this could be a sign that they are not eating the correct foods. When you are teaching your children good dental and life habits; be sure not to leave out the positive impact proper eating and exercise habits can have as well.
The guidelines we?ve covered in this article can help to teach your kids good habits when it comes to keeping their teeth healthy. Cavities are inevitable, a part of life that may occur regardless of what preventative measures you take. Cavities are less likely to appear if your children stay away from junk food like candy bars and gum. Yet parents can still do a lot to help educate their kids on the importance of dental health.
Angela from Mowbray Place is the owner of a child care centre found in Willoughby. She has two children of her own and is aware how tricky it can be to be a working mom. The benefit of owning a child care centre is that she can take care of her children as well as other kids at the same time.
EDGEFIELD, S.C. --(Ammoland.com)- NWTF has partnered with Armed Forces Entertainment and Paralyzed Veterans of America?s Outdoor Recreation Heritage Fund to participate in the first Outdoor Legends Tour.
NWTF CEO George C. Thornton, NWTF spokespersons Brenda Valentine and Michael Waddell, NWTF Foundation Board member Ryan Klesko and a number of other famous outdoorsmen will tour Europe and Southwest Asia military bases this spring to visit active-duty United States military personnel.
Thornton and Mossy Oak?s Ronnie ?Cuz? Strickland worked closely with tour creator, retired U.S. Marine Corps Lt. Col. Lew Deal, to recruit outdoor industry celebrities to participate in the tour.
Deal and retired USMC Maj. Gen. Randy West, an Outdoor Recreation Heritage Fund board member, will lead Thornton, Valentine, Waddell, Strickland and fellow celebrity outdoor personalities Jim Zumbo, Jim Shockey, Jerry Martin and Bill Miller on the 10-day tour.
?For those currently serving in a war zone there are few things that mean as much as knowing the folks back home care about you,? said Deal. ?It?s a hand-shake tour. There will be no production crews, no agents or sponsors ? just high-profile outdoor people mingling, posing for photos with the troops and thanking them for their service.?
The outdoor industry is now included among a prestigious group of musicians, comedians, actors and actresses who have visited American military personnel stationed overseas to thank them for sacrifices they have made during tours of duty.
?When Lt. Col. Deal approached me with this opportunity several months ago, my heart swelled with honor,? said Thornton. ?That I was asked to go, not as an individual but as a representative of the entire NWTF membership, is at the very least humbling. I can?t wait to express NWTF members? support and appreciation for our servicemen and women and offer our prayers for their wellbeing and a safe, speedy return home.?
For safety reasons, the exact location of the visits of the Outdoors Legends Tour can?t be disclosed until after the tour is complete. Thornton will blog about the trip on a regular basis and updates can be found at www.nwtf.org or www.facebook.com/theNWTF.
Armed Forces Entertainment is the Department of Defense agency responsible for providing the very best in American entertainment to American military personnel stationed overseas. Outdoor Recreation Heritage Fund supports PVA?s outdoor sports programs, including fishing, hand cycling and triathlon, track and field events and recreational shooting and hunting.
About the NWTF: The NWTF is the leader in upland wildlife habitat conservation in North America. A nonprofit organization dedicated to conserving the wild turkey and preserving our hunting heritage, the NWTF and its volunteers work closely with state, federal and provincial wildlife agencies and other partners. Through these dynamic partnerships, the NWTF and its members helped restore wild turkey populations throughout North America, investing more than $372 million to conserve 17 million acres of essential wildlife habitat. The NWTF also brings new conservationists and hunters into the fold through outdoor education programs and dedicated NWTF volunteers introduce about 100,000 people to the outdoors through these programs every year.
To become a member of the NWTF, join a committee or start a chapter, visit www.nwtf.org or call 800-THE-NWTF. The NWTF is also at www.facebook.com/theNWTF.
Tags: OIA, Outdoors Personalities, Shooting Industry News, Shooting Media News, Troop Support
A class action lawsuit filed by owners of faulty Sammy TVs has finally reached a settlement. The manufacturer has promised to foot the bill for new repairs, reimburse for previous repairs and hand out up to $300 to customers who no longer possess their broken TVs but can prove they once did. The fault can affects any of the models listed above -- possibly up to seven million sets in total -- and centers on an errant capacitor in the power circuit that stops the TV turning on, makes it slow to turn on, produces a "clicking sound" or makes it cycle on and off. If you think you're affected then check the source link for details on what to do next. Curious to know how much the lawyers got? A cool half-million for their troubles, which means they'll be upgrading to OLED.
Question: A Turkish friend of mine asked me for money because his baby was born in the hospital, and he didn?t have any money. I thought Turkey had a national healthcare system. Could you explain the Turkish healthcare system?
Answer: The healthcare system goes along with the retirement system in Turkey. There are three healthcare-retirement systems in Turkey. All three systems are similar in that they are a part of the Social Insurance Institution (SSK), and each group pays a percentage of their monthly income, usually matched by their employers to the system in return for free doctor visits and low-cost medicine
The three divisions are for workers hired by the state, companies and factories; workers hired by the government; and people who are self-employed like businessmen, shop-owners, farmers, and others.
People who do not fall into any of these three categories above, like a gardener or maid, could go to the state-run hospitals for treatment, but they pay for some of the additional expenses at the hospital.
Although there are three systems, there are not enough doctors and beds in the insurance and state hospitals.
There are always long lines to see a doctor or get medicine from the hospital pharmacy. In order to receive better medical treatment, nearly everyone prefers to go to private doctors and private hospitals, which cost more.
Regardless of those three categories and who the patient is, some diseases like tuberculosis, AIDS, malaria and other contageous diseases are subject to be reported and treated free of charge by the state hospital.
People who do not fall into any of these three categories above, like a gardener or maid, could go to the state-run hospitals for treatment, but they pay for some of the additional expenses at the hospital.
Although there are three systems, there are not enough doctors and beds in the insurance and state hospitals.
There are always long lines to see a doctor or get medicine from the hospital pharmacy. In order to receive better medical treatment, nearly everyone prefers to go to private doctors and private hospitals, which cost more.
Regardless of those three categories and who the patient is, some diseases like tuberculosis, AIDS, malaria and other
of these three categories above, like a gardener or maid, could go to the state-run hospitals for treatment, but they pay for some of the additional expenses at the hospital.
Although there are three systems, there are not enough doctors and beds in the insurance and state hospitals. There are always long lines to see a doctor or get medicine from the hospital pharmacy. In order to receive better medical treatment, nearly everyone prefers to go to private doctors and private hospitals, which cost more
The three divisions are for workers hired by the state, companies and factories; workers hired by the government; and people who are self-employed like businessmen, shop-owners, farmers, and others.
People who do not fall into any of these three categories above, like a gardener or maid, could go to the state-run hospitals for treatment, but they pay for some of the additional expenses at the hospital.
Although there are three systems, there are not enough doctors and beds in the insurance and state hospitals. There are always long lines to see a doctor or get medicine from the hospital pharmacy. In order to receive better medical treatment, nearly everyone prefers to go to private doctors and private hospitals, which cost more.
Regardless of those three categories and who the patient is, some diseases like tuberculosis, AIDS, malaria and other contageous diseases are subject to be reported and treated free of charge by the state hospitals
If you bought a defective item, chances are you will notice it within a few weeks only. Extended warranties are just a way for the business to make an extra buck, but they?ll rarely be worthwhile for the user.
Reflect upon financial mistakes you have made in the past, and learn from them. Spending years recovering from credit card debt can be a learning experience to discourage further credit card use. If you have been overworked and underpaid, remember that when you negotiate salary terms for your next position. As you review your history of personal finances in your mind?s eye, realize that every lesson you can learn from your experiences is worthwhile. Pay attention to the lessons you learn from your finances, and over time you will be financially solid and in a better place.
If you want a mortgage, you should have a credit score of 740. You will get better interest rate with this kind of scores. If your credit is less than perfect there are steps you can take to repair it. It will be beneficial to your finances to wait on getting a mortgage if you have a poor credit score.
It is never too late to open a savings account and take back control of your finances. You should stop procrastinating about setting up a savings plan. Set aside a fixed amount each payday and put it towards savings. Eventually you will have a cushion financially that can be relied on.
Learning to cook like a five-star chef can save you lots of money that you would have spent eating out. A healthy and delicious meal for your family can easily be prepared for $25-30. You can easily spend that much on a couple of fast food burgers and some soda.
Try making presents instead of buying them. Instead of spending time shopping, you can spend time being crafty and making your presents. You can also reduce costs and boost your net worth by being creative.
This fund should not contain under three months income. Simply invest ten percent of each paycheck into a high yield account regularly.
Track how much you spend each month and then figure out a budget based on your records. Perhaps a part of your money is not spent wisely. Regardless of how much you earn, a good financial situation is about managing your budget. Personal finances software will make the process easier and less stressful. If you end the month with some money remaining, pay past-due bills or sock it away in an online savings account.
Making regular deposits to a savings account is important for your financial stability. Having enough savings on hand means you won?t have to use your credit cards or take out a loan in cases of an emergency. Even small deposits on a monthly basis will help your savings grow, and your nest egg increase.
Work to keep your credit rating as high as possible. If you want to have low interest on a loan or credit card, you will need to have a good credit score. Even basic utilities and rent can be impacted by low beacon scores on your credit. Only take out credit that you will be able to afford and be timely with, to get your rating higher.
Explore online banking if you think this could help you manage your finances. There are websites out there that have software programs that you can use to categorize expenses, track cash flows, and calculate interest. All of which you can use to create a reasonable budget for yourself.
Using small steps can help to rebuild your personal finances. Forgo that daily stop at the cafe and make your own coffee instead. This can help you save $25 per week. You can save money by taking the bus to work instead of driving. Do not underestimate how much you can save over the long run. These small amounts of money add up quickly, and you can put those funds towards bigger and better things. Enjoying such rewards can be sweeter than any cup of coffee.
Knowing and understanding your personal finances is one of the best tools to equip yourself with. You should always know where your money is going, it will make everything easier. Follow these ideas and you will be on your way to maximizing your income and making good progress towards your financial goals.
Bad retirement planning, which tends to result in a shortfall of retirement funds, is common among a lot of American workers. Women seem to be hit harder by the recession and generally accumulate smaller nest eggs than men because of a number of factors.
Women usually make less money throughout their working years in comparison to men ? this directly influences how much they contribute to retirement plans and accounts such as 401Ks, resulting in inadequate retirement funds. Giving birth and rearing children often stops women from pursuing their careers, temporarily or permanently, also interrupting their contributions to pension plans and Social Security. Lastly, statistics say that women invest more conservatively than men, meaning their portfolios don?t have as much potential for growth during their younger years, which is when investing should be aggressive.
Even women in the middle-income to high-income brackets are at risk of not having enough to retire on. The Social Security Administration reported that 17% of all single women aged upwards of 64 made less than $ 10,326 (the poverty threshold) 2 years ago.
Concerns about retirement security further multiplied because of the recession. A Transamerica Center for Retirement Studies survey of approximately 3,600 workers showed an increased lack of confidence in reaching retirement goals. 94% of all surveyed weren?t sure they would be able to live a comfortable retirement, while 77% of all female respondents said their savings and investments would not amount to ample retirement funds. Despite more women having access to employer-sponsored retirement plans last year, only 70% of these workers participated.
If you?re worried about not having enough to live on when you retire, there are a few things you can do to build retirement security despite the barriers you face. Start by getting educated and rethinking your financial strategies. Consult with your financial advisor to know more about how you can invest better and make the most out of your retirement plan.
Carina Smith is an author that specializes in financial topics concerning seniors. Puritan Financial Group specializes in helping retirees overcome the obstacles to retirement security with stable investments. For more information about how Puritan Financial Group can help you, please visit our website at http://www.puritanlife.com
[unable to retrieve full-text content]AP - Australia's foreign minister resigned Wednesday in a bitter rift with Prime Minister Julia Gillard, who may poll her party's lawmakers next week on who should lead the country.
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?Offshore Rig Construction Market to 2015 and Current Rig Deployment Scenario - Acquisition of Rivals a Prominent Strategic Option?. The study, which is an offering from the company?s Energy Research Group, provides an in-depth analysis of the global offshore rig construction market and highlights various concerns, key trends and challenges, along with major companies in the industry. The report provides forecasts for the offshore rig construction industry to 2015. It also provides segmental forecasts of the offshore rig construction market worldwide by rig type, and provides comprehensive data on current offshore rigs deployed globally, by rig type. The report also provides in-depth information on new build rig orders by major offshore drilling contractors, by country of rig manufacturing shipyard, and expected new builds and their expected deployment time. The report is built using data and information sourced from proprietary databases, primary and secondary research, and in-house analysis by GBI Research?s team of industry experts. http://www.bharatbook.com/market-research-reports/energy-market-research-report/offshore-rig-construction-market-to-2015-and-current-rig-deployment-scenario-acquisition-of-rivals-a-prominent-strategic-option.html ? ?As most countries which possess commercial potential in terms of their offshore reserves seek to achieve energy self-sufficiency, the offshore exploration and production industry is expected to make significant investments in the discovery and development of new offshore reserves. In turn, this will lead to infrastructure investments by exploration and production companies in the form of new build offshore rigs, particularly for untapped shallow water regions with exploration potential. Subsequently, offshore rig construction expenditure is expected to rise from 2011?2015. market to market
? ?As shallow water drilling activity is expected to substantially rise, the business potential for harshenvironment and premium and ultra-premium jack-up rig construction companies is expected to be strong. Also, at present, rig contractors prefer to acquire rival companies as part of their business strategy in order to gain a competitive edge. ? ?Scope ?The report provides in-depth analysis of the major factors affecting the offshore rig construction industry worldwide. Its scope includes - ?- Overview and analysis of the global offshore rig construction market to 2015 ?- Analysis of the historical trends and forecasts to 2015 ?- Segmental forecasts of offshore rig construction expenditure, by rig type ?- Country-specific data with regard to new builds ?- Comprehensive data of currently deployed offshore rigs, by rig type ?- Analysis of the opportunities and challenges in the global offshore rig construction industry ? ?Reasons to buy ?- Develop business strategies with the help of specific insights about the global offshore rig construction industry and the offshore rig deployment situation. ?- Identify key trends and challenges in the global offshore rig construction industry. ?- Increase future revenues and profitability with the help of insight into the expected demandsupply scenario for offshore rigs worldwide. ?- Benchmark your operations and strategies using key insights from current and expected business developments with regard to the offshore rig construction industry. ? ?For more information kindly visit : ?Offshore Rig Construction Market to 2015 and Current Rig Deployment Scenario - Acquisition of Rivals a Prominent Strategic Option ? ?Or ? ?Bharat Book Bureau ?Tel: +91 22 27810772 / 27810773 ?Fax: + 91 22 27812290 ?Email: info@bharatbook.com ?Website: www.bharatbook.com ?Follow us on twitter: http://twitter.com/#!/Sandhya3B
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