In the novel, Goldratt lays out what he terms a "theory of constraints." The idea is that the success of an entire factory (or, in fact, of any process at all) is determined by the choke point that constrains the overall output. In other words, the whole factory can only move as fast as its slowest element. This bottleneck could occur at the beginning of the process, the middle, or the end. It could be an outdated machine, an incompetent worker, or a stupid company-wide regulation. But whatever the bottleneck is, every action should be taken with it in mind, and every resource should be directed at eliminating it. Once the worst bottleneck is identified and vaporized, you go hunting for the next worst, and then the next.
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